01831nas a2200229   4500008004100000020002200041245009100063210006900154260005100223300001200274490000600286520111700292653001901409100001701428700001501445700001501460700001301475700001801488700002001506700001701526856005801543       2011                        eng d  a978-3-642-18055-200a{Inherently Bio-Active Scaffolds: Intelligent Constructs to Model the Stem Cell Niche}0 aInherently BioActive Scaffolds Intelligent Constructs to Model t  aBerlin, HeidelbergbSpringer Berlin Heidelberg  a29–470 v63 a<p>The oft-abused phrase â€œgenes load the gun, environment pulls the triggerâ€ can be applied to stem cells and stem cell niches as well as to cellâ€“material interfaces. Much is known about cellâ€“material interaction in general, perhaps a little less about how these interactions condition cell phenotype. With the increasing interest in stem cells and, in particular, their applications in tissue regeneration, the regulation of the stem cell microenvironment through modulation of intuitive or smart materials and structures, or what we term IBAS (Inherently Bio-Active Scaffolds) is poised to become a major field of research. Here, we discuss how cardiac regeneration strategies have undergone a gradual shift from the emphasis on biochemical signals and basic biology to one in which the material or scaffold plays a major role in establishing an equilibrium state. From being a constant battle or tug-of-war between the cells and synthetic environments, we conceive IBAS as intuitively responding to the cellâ€™s requirements to instate a sort of equilibrium in the system.</p>
10aBioengineering1 aDi Nardo, P.1 aMinieri, M1 aTirella, A1 aForte, G1 aAhluwalia, A.1 aBoccaccini, A R1 aHarding, S E  uhttp://www.springerlink.com/content/j3k541l113233424/