00782nas a2200217 4500008004100000245009400041210006900135490000600204653002800210653001800238653002500256653003700281653002000318100001800338700001800356700001500374700001700389700001700406700001700423856012400440 2017 eng d00aA Multimodal Perception Framework for Users Emotional State Assessment in Social Robotics0 aMultimodal Perception Framework for Users Emotional State Assess0 v910ahuman-robot interaction10amultimodality10aperception framework10aphysiological signal acquisition10asocial robotics1 aCominelli, L.1 aCarbonaro, N.1 aMazzei, D.1 aGarofalo, R.1 aTognetti, A.1 aDe Rossi, D. uhttp://95.110.227.16/publications/multimodal-perception-framework-users-emotional-state-assessment-social-robotics.html03563nas a2200205 4500008004100000022002200041245010600063210006900169260003300238300001400271520283400285653001903119100001503138700001403153700001403167700001803181700001703199700001703216856012403233 2011 eng d a978-1-62100-164-500aMulti-Compartmental Modular Bioreactor as Innovative System for Dynamic Cell Cultures and Co-Cultures0 aMultiCompartmental Modular Bioreactor as Innovative System for D bNova Science Publishers, Inc a159 - 1783 a

In this chapter, the design, fabrication process and preliminary tests of a Multi- Compartmental Modular Bioreactor used as a system for dynamic cell cultures and co-cultures is described. Although the microwell (MW) plate has become a standard in cell culture, the complexity of the physiological environment is not replicated in petri dishes or microplates. All cells are exquisitely sensitive to their micro-environment which is rich with cues from other cells and from mechanical stimuli due to flow, perfusion and movement. Microwells do not offer any form of dynamic chemical or physical stimulus to cells, such as concentration gradients, flow, pressure or mechanical stress. This is a major limitation in experiments investigating cellular responses in-vitro since the complex interplay of mechanical and biochemical factors is absent. Most researchers and industry have started to accept that classical in vitro experiments offer poor predictive value or mechanistic understanding and are shifting their interests to new technologies such as bioreactors. For this reason, a large number of bioreactor systems for cell culture have been recently designed and described. With the purpose of developing cell culture models to establish a physiological-like interaction between different cell types, a novel Multi-Compartmental Modular Bioreactor (MCmB)was realized. The modular chamber was designed with shape and dimensions similar to the 24-MultiWell allowing an easy transfer of microwell protocols. The MCmB consists of a cell culture chamber made of bio-compatible silicon polymer, with excellent self-sealing proprieties, transparency and flexibility. The modular chambers can be also connected together in series or in parallel as desired, in order to allow cell-cell cross-talk or replicate in vitro models of metabolism or diseases using allometric design principles. In this chapter we describe the bioreactor design process starting from a finite-element method (FEM) model, developed in order to study the shear stress and the oxygen concentration at the cell surface. A further version of the MCmB is also described, in which a semipermeable membrane is placed into the bioreactor allowing to create a double-chamber system (MCmB-dc) for biological barriers simulation like for example lung or intestine. Allometric methods for designing in-vitro organ models using combinations of different cell types or tissues cultured in different chambers are also presented. Allometric laws mathematically correlate non linear quantities such as organ mass, blood flow, blood retention time and metabolic rate. Using these laws the modules can be assembled in various configurations enabling organ and system physiology to be recapitulated in vitro. Preliminary experiments using the modules are also described.

10aBioengineering1 aMazzei, D.1 aGiusti, S1 aSbrana, T1 aAhluwalia, A.1 aAntolli, P G1 aLiu, Zhiming uhttp://95.110.227.16/publications/multi-compartmental-modular-bioreactor-innovative-system-dynamic-cell-cultures-and-co01726nas a2200193 4500008004100000022001400041245007900055210006900134300001200203490000700215520110400222653001901326100001501345700001601360700001501376700001601391700001301407856011201420 2010 eng d a0938-010800aModification of Pointing Performance in Altered Gravitational Environments0 aModification of Pointing Performance in Altered Gravitational En a123-1280 v223 a

The Fitts’ law describes a correlation between the time needed to complete basic tasks such as pointing movements and the level of knowledge of the specific target to be reached. While it has been largely proved in normal gravity, very few experiments have been carried out in altered gravitational conditions. In our experiment, four subjects were positioned in front of a panel where round targets were placed along a circumference. They carried out pointing movements towards the targets when these were switched on. The task time was acquired and processed off-line. In all the cases, the performance of each subject have been significantly modified in the altered gravitational environment and, in particular, hypergravity seems to affect motor performance more considerably than microgravity. Even if experiments involving several subjects and more complex tasks have to be carried out in order to confirm our findings, these results show that ergonomics could be strongly affected by the modification of gravity, especially during the first phase of exposure to gravity alteration.

10aBioengineering1 aCiofani, G1 aMigliore, A1 aMazzei, D.1 aCarrozza, M1 aDario, P uhttp://95.110.227.16/publications/modification-pointing-performance-altered-gravitational-environments.html00538nas a2200169 4500008003900000245005500039210005500094260002000149300000800169520002000177653001900197100001500216700001500231700001400246700001800260856009000278 2008 d00aMicrofluidic Gradient Maker for Pattern Generation0 aMicrofluidic Gradient Maker for Pattern Generation aPorto, Portugal a8793 a

poster

10aBioengineering1 aTirella, A1 aMazzei, D.1 aVozzi, G.1 aAhluwalia, A. uhttp://95.110.227.16/publications/microfluidic-gradient-maker-pattern-generation.html00400nas a2200133 4500008004100000022001400041245003600055210003500091653001900126100001800145700001500163700001300178856007500191 2008 eng d aP122454GB00aMULTI-CAVITY BIOREACTOR CHAMBER0 aMULTICAVITY BIOREACTOR CHAMBER10aBioengineering1 aAhluwalia, A.1 aMazzei, D.1 aVinci, B uhttp://95.110.227.16/publications/multi-cavity-bioreactor-chamber.html