@conference {2495, title = {Damasio{\textquoteright}s Somatic Marker for Social Robotics: Preliminary Implementation and Test}, booktitle = {Living Machines - The 4th International Conference on Biomimetic and Biohybrid Systems}, year = {2015}, pages = {316-328}, publisher = {Springer}, organization = {Springer}, address = {Barcelona, Spain, 28 - 31 July 2015}, keywords = {Bioengineering}, url = {http://link.springer.com/chapter/10.1007/978-3-319-22979-9_31$\#$page-1}, author = {Cominelli, L. and D. Mazzei and M. Pieroni and A. Zaraki and R. Garofalo and D. De Rossi} } @article {2497, title = {Improving African Healthcare through Open Source Biomedical Engineering}, journal = {International Journal On Advances in Life Sciences}, year = {2015}, month = {01/2015}, keywords = {Bioengineering}, author = {C. De Maria and D. Mazzei and A. Ahluwalia} } @conference {2504, title = {Open Biomedical Engineering Education in Africa}, booktitle = {The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)}, year = {2015}, publisher = {IEEE}, organization = {IEEE}, address = { Milan, Italy, 25-29 August 2015}, keywords = {Bioengineering}, author = {A. Ahluwalia and D. Atwine and C. De Maria and C. Ibingira and E. Kipkorir and F. Kiros and J. Madete and D. Mazzei and E. Molyneux and K. Moonga and M. Moshi and M. Nzomo and V. Oduol and J. Okuonzi} } @conference {2190, title = {Open Source Biomedical Engineering for Sustainability in African Healthcare: Combining Academic Excellence with Innovation}, booktitle = {ICDS 2014, The Eighth International Conference on Digital Society}, year = {2014}, pages = {48{\textendash}53}, keywords = {Bioengineering}, author = {C. De Maria and D. Mazzei and A. Ahluwalia} } @conference {2187, title = {Recognition and Expression of Emotions by a Symbiotic Android Head}, booktitle = {IEEE-RAS International Conference on Humanoid Robots (HUMANOIDS 2014)}, year = {2014}, pages = {134 - 139 }, publisher = {IEEE}, organization = {IEEE}, address = {Madrid, Spain, November 18 - 20}, keywords = {Bioengineering, Robotics}, doi = {10.1109/HUMANOIDS.2014.7041349}, author = {D. Mazzei and A. Zaraki and Lazzeri, N. and D. De Rossi} } @conference {2188, title = {An RGB-D Based Social Behavior Interpretation System for a Humanoid Social Robot}, booktitle = {IEEE-RSI International Conference on Robotics and Mechatronics 2014 }, year = {2014}, pages = {185 - 190}, publisher = {IEEE}, organization = {IEEE}, address = {Tehran, Iran, October 15-17}, keywords = {Bioengineering, Robotics}, doi = {10.1109/ICRoM.2014.6990898}, author = {A. Zaraki and Giuliani, M. and Dehkordi, M. B. and D. Mazzei and D{\textquoteright}Ursi, A. and D. De Rossi} } @conference {2275, title = {Sensorized Squeeze Pressure Bioreactor For mechanical modulation of cardiomyocyte phenotype}, booktitle = {Journal of tissue engineering and regenerative medicine}, volume = {8 Suppl 1}, year = {2014}, pages = {67{\textendash}8}, keywords = {Bioengineering}, doi = {10.1002/term.1943}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24912686}, author = {S. Giusti and Vozzi, F. and F. Pagliari and Tirella, A and D. Mazzei and Cabiati, M and S. del Ry and A. Ahluwalia} } @article {2241, title = {Wearable Wireless Tactile Display for Virtual Interactions with Soft Bodies}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {2}, year = {2014}, abstract = {

We describe here a wearable, wireless, compact, and lightweight tactile display, able to mechanically stimulate the fingertip of users, so as to simulate contact with soft bodies in virtual environments. The device was based on dielectric elastomer actuators, as high-performance electromechanically active polymers. The actuator was arranged at the user{\textquoteright}s fingertip, integrated within a plastic case, which also hosted a compact high-voltage circuitry. A custom-made wireless control unit was arranged on the forearm and connected to the display via low-voltage leads. We present the structure of the device and a characterization of it, in terms of electromechanical response and stress relaxation. Furthermore, we present results of a psychophysical test aimed at assessing the ability of the system to generate different levels of force that can be perceived by users.

}, keywords = {Bioengineering}, doi = {10.3389/fbioe.2014.00031}, url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150388/}, author = {G. Frediani and D. Mazzei and D. De Rossi and F. Carpi} } @conference {1812, title = {Advanced Interfaces to Stem the Data Deluge in Mixed Reality: Placing Human (un)consciuosness in the Loop}, booktitle = {ACM SIGGRAPH 2013}, year = {2013}, address = {New York, NY, USA}, keywords = {Bioengineering}, url = {10.1145/2503385.2503460}, author = {A. Betella and E. Mart{\`\i}nez and R. Zucca and X. D. Arsiwalla and P Omedas and S. Wierenga and A. Mura and J. Wagner and F. Lingenfelser and E. Andr{\'e} and D. Mazzei and A. Tognetti and A Lanata and D. De Rossi and P. F. M. J. Verschure} } @inbook {1810, title = {Preliminary Implementation of Context-Aware Attention System for Humanoid Robots}, booktitle = {Biomimetic and Biohybrid Systems (Proc. Second International Conference, Living Machines 2013)}, volume = {8064}, number = {Lecture Notes in Computer Science}, year = {2013}, pages = {457-459}, publisher = {Springer-Verlag}, organization = {Springer-Verlag}, abstract = {

A context-aware attention system is fundamental for regulating the robot behaviour in a social interaction since it enables social robots to actively select the right environmental stimuli at the right time during a multiparty social interaction. This contribution presents a modular context-aware attention system which drives the robot gaze. It is composed by two modules: the scene analyzer module manages incoming data flow and provides a human-like understanding of the information coming from the surrounding environment; the attention module allows the robot to select the most important target in the perceived scene on the base of a computational model. After describing the motivation, we report the proposed system and the preliminary test.

}, keywords = {Bioengineering}, issn = {978-3-642-39801-8}, doi = {10.1007/978-3-642-39802-5_65}, author = {A. Zaraki and D. Mazzei and Lazzeri, N. and M. Pieroni and D. De Rossi} } @article {2281, title = {SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype}, journal = {Procedia Engineering}, volume = {59}, year = {2013}, pages = {219{\textendash}225}, abstract = {

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.

}, keywords = {Bioengineering}, issn = {18777058}, doi = {10.1016/j.proeng.2013.05.114}, url = {http://linkinghub.elsevier.com/retrieve/pii/S187770581301028X}, author = {S. Giusti and F. Pagliari and Vozzi, F. and Tirella, A and D. Mazzei and Cabiati, M and S. del Ry and A. Ahluwalia} } @inbook {1811, title = {Towards a Believable Social Robot}, booktitle = {Biomimetic and Biohybrid Systems (Proc. Second International Conference, Living Machines 2013)}, number = {Lecture Notes in Computer Science}, year = {2013}, pages = {393-395}, publisher = {Springer-Verlag}, organization = {Springer-Verlag}, abstract = {

Two perspectives define a human being in his social sphere: appearance and behaviour. The aesthetic aspect is the first significant element that impacts a communication while the behavioural aspect is a crucial factor in evaluating the ongoing interaction. In particular, we have more expectations when interacting with anthropomorphic robots and we tend to define them believable if they respect human social conventions. Therefore researchers are focused both on increasingly anthropomorphizing the embodiment of the robots and on giving the robots a realistic behaviour.This paper describes our research on making a humanoid robot socially interacting with human beings in a believable way.

}, keywords = {Bioengineering}, issn = {978-3-642-39801-8}, doi = {10.1007/978-3-642-39802-5_45}, author = {Lazzeri, N. and D. Mazzei and A. Zaraki and D. De Rossi} } @conference {1265, title = {HEFES: an Hybrid Engine for Facial Expressions Synthesis to control human-like androids and avatars}, booktitle = {BIOROB2012}, year = {2012}, pages = {195 - 200}, address = {Rome, Italy}, keywords = {Bioengineering}, author = {D. Mazzei and Lazzeri, N. and Hanson, D. and D. De Rossi} } @conference {2282, title = {Real Time and In-Situ control of environmental parameters in a modular bioreactor}, booktitle = {Journal of tissue engineering and regenerative medicine}, volume = {6 Suppl 1}, year = {2012}, pages = {331}, address = {Vien, Austria}, abstract = {

Many researchers now recognize the importance of the external environment in which cells are cultured for cell function and differentiation. Most of the systems able to apply physiological-like stimuli also need a classical incubator or a specifically designed system to control the environmental parameters at some distance from the cells. Here, a standalone platform for cell, tissue and organ culture is described. The SUITE (Supervising Unit for In-vitro Testing) system can control local environmental variables like pH, temperature and hydrostatic pressure over long periods, to provide the optimal environment for cells outside the classical incubator and also to apply mechanical and chemical stimuli to simulate the physiological milieu. The SUITE platform is used with Multi-Compartmental modular Bioreactors (MCmB) to perform dynamic cultures of hepatocytes as in-vitro liver model. Preliminary tests demonstrated the capability of the system to maintain the target parameters for more than 72 h generating different hydrostatic pressures (20{\^a}{\texteuro}{\textquotedblleft}30{\^a}{\texteuro}{\textquotedblleft}40{\^a}{\texteuro}{\textquotedblleft}50 mmHg). Then, two bioreactors were connected in series and cultured for 24 h in the SUITE platform with hydrostatic pressures of 20{\^a}{\texteuro}{\textquotedblleft}30{\^a}{\texteuro}{\textquotedblleft}40 mmHg. Static and dynamic controls were placed in the classical humidified incubator at 37{\^A}{\textdegree}C, 5\% CO2. The results show that cell function is enhanced in SUITE at up to 30 mmHg of hydrostatic pressure, as confirmed by viability, metabolic function and morphological analysis.

}, keywords = {Bioengineering}, doi = {10.1002/term.1586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22941753}, author = {S. Giusti and D. Mazzei and A. Ahluwalia} } @conference {1264, title = {Realistic Humanlike Robots for Treatment of ASD, Social Training, and Research; Shown to Appeal to Youths with ASD, Cause Physiological Arousal, and Increase Human-to-Human Social Engagement}, booktitle = {Realistic Humanlike Robots for Treatment of Autism, PETRA 2012}, year = {2012}, pages = {1-7}, keywords = {Bioengineering}, author = {Hanson, D. and D. Mazzei and Garver, C. and D. De Rossi and Stevenson, M.} } @conference {1272, title = {Development and evaluation of a social robot platform for therapy in autism}, booktitle = {Proc. Annual Int Engineering in Medicine and Biology Society,EMBC Conf. of the IEEE}, year = {2011}, pages = {4515{\textendash}4518}, keywords = {Bioengineering}, doi = {10.1109/IEMBS.2011.6091119}, author = {D. Mazzei and Lazzeri, N. and Billeci, L. and Igliozzi, R. and A Mancini and A. Ahluwalia and Muratori, F. and D. De Rossi} } @article {1279, title = {Dispositivo per tomografia ad impedenza elettrica}, year = {2011}, keywords = {Bioengineering}, issn = {PI2011A000124}, author = {Baldi, G. and D. Mazzei and Gervasi, V.} } @article {1285, title = {A flexible bioreactor system for constructing in vitro tissue and organ models.}, journal = {Biotechnol Bioeng}, volume = {108}, year = {2011}, month = {Sep}, pages = {2129{\textendash}2140}, abstract = {

To develop in vitro models of cells, tissues and organs we have designed and realized a series of cell culture chambers. Each chamber is purpose designed to simulate a particular feature of the in vivo environment. The bioreactor system is user friendly, and the chambers are easy to produce, sterilize and assemble. In addition they can be connected together to simulate inter-organ or tissue cross-talk. Here we discuss the design philosophy of the bioreactor system and then describe its construction. Preliminary results of validation tests obtained with hepatocytes and endothelial cells are also reported. The results show that endothelial cells are extremely sensitive to small levels of shear stress and that the presence of heterotypic signals from endothelial cells enhances the endogenous metabolic function of hepatocytes.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.1002/bit.23164}, author = {Vozzi, F. and D. Mazzei and Vinci, B. and G. Vozzi and Sbrana, T. and Ricotti, L. and Forgione, N. and A. Ahluwalia} } @article {1277, title = {High throughput sensorized bioreactor for applying hydrodynamic pressure and shear stress stiumli on cell cutlures}, year = {2011}, month = {10/2011}, keywords = {Bioengineering}, issn = {WO 2011/121377}, author = {A. Ahluwalia and C. De Maria and D. Mazzei and G. Vozzi} } @inbook {1286, title = {Multi-Compartmental Modular Bioreactor as Innovative System for Dynamic Cell Cultures and Co-Cultures}, booktitle = {Bioreactors: Design, Properties and Applications}, number = {978-1-62100-164-5}, year = {2011}, pages = {159 - 178}, publisher = {Nova Science Publishers, Inc}, organization = {Nova Science Publishers, Inc}, chapter = {Multi-Compartimental Modular Bioreactor as Innovative System for Dynamic Cell Cultures and Co-Cultures}, abstract = {

In this chapter, the design, fabrication process and preliminary tests of a Multi- Compartmental Modular Bioreactor used as a system for dynamic cell cultures and co-cultures is described. Although the microwell (MW) plate has become a standard in cell culture, the complexity of the physiological environment is not replicated in petri dishes or microplates. All cells are exquisitely sensitive to their micro-environment which is rich with cues from other cells and from mechanical stimuli due to flow, perfusion and movement. Microwells do not offer any form of dynamic chemical or physical stimulus to cells, such as concentration gradients, flow, pressure or mechanical stress. This is a major limitation in experiments investigating cellular responses in-vitro since the complex interplay of mechanical and biochemical factors is absent. Most researchers and industry have started to accept that classical in vitro experiments offer poor predictive value or mechanistic understanding and are shifting their interests to new technologies such as bioreactors. For this reason, a large number of bioreactor systems for cell culture have been recently designed and described. With the purpose of developing cell culture models to establish a physiological-like interaction between different cell types, a novel Multi-Compartmental Modular Bioreactor (MCmB)was realized. The modular chamber was designed with shape and dimensions similar to the 24-MultiWell allowing an easy transfer of microwell protocols. The MCmB consists of a cell culture chamber made of bio-compatible silicon polymer, with excellent self-sealing proprieties, transparency and flexibility. The modular chambers can be also connected together in series or in parallel as desired, in order to allow cell-cell cross-talk or replicate in vitro models of metabolism or diseases using allometric design principles. In this chapter we describe the bioreactor design process starting from a finite-element method (FEM) model, developed in order to study the shear stress and the oxygen concentration at the cell surface. A further version of the MCmB is also described, in which a semipermeable membrane is placed into the bioreactor allowing to create a double-chamber system (MCmB-dc) for biological barriers simulation like for example lung or intestine. Allometric methods for designing in-vitro organ models using combinations of different cell types or tissues cultured in different chambers are also presented. Allometric laws mathematically correlate non linear quantities such as organ mass, blood flow, blood retention time and metabolic rate. Using these laws the modules can be assembled in various configurations enabling organ and system physiology to be recapitulated in vitro. Preliminary experiments using the modules are also described.

}, keywords = {Bioengineering}, issn = {978-1-62100-164-5}, author = {D. Mazzei and S. Giusti and Sbrana, T. and A. Ahluwalia}, editor = {Antolli, P. G. and Zhiming Liu} } @article {2284, title = {Squeeze pressure bioreactor: a hydrodynamic bioreactor for noncontact stimulation of cartilage constructs}, journal = {Tissue engineering. Part C, Methods}, volume = {17}, year = {2011}, pages = {757{\textendash}64}, abstract = {

A novel squeeze pressure bioreactor for noncontact hydrodynamic stimulation of cartilage is described. The bioreactor is based on a small piston that moves up and down, perpendicular to a tissue construct, in a fluid-filled chamber. Fluid displaced by the piston generates a pressure wave and shear stress as it moves across the sample, simulating the dynamic environment of a mobile joint. The fluid dynamics inside the squeeze pressure bioreactor was modeled using analytical and computational methods to simulate the mechanical stimuli imposed on a construct. In particular, the pressure, velocity field, and wall shear stress generated on the surface of the construct were analyzed using the theory of hydrodynamic lubrication, which describes the flow of an incompressible fluid between two surfaces in relative motion. Both the models and in-situ pressure measurements in the bioreactor demonstrate that controlled cyclic stresses of up to 10 kPa can be applied to tissue constructs. Initial tests on three-dimensional scaffolds seeded with chondrocytes show that glycosaminoglycan production is increased with regard to controls after 24 and 48 h of cyclic noncontact stimulation in the bioreactor.

}, keywords = {Bioengineering}, issn = {1937-3392}, doi = {10.1089/ten.TEC.2011.0002}, url = {http://online.liebertpub.com/doi/abs/10.1089/ten.tec.2011.0002 http://www.ncbi.nlm.nih.gov/pubmed/21410315}, author = {C. De Maria and S. Giusti and D. Mazzei and A. Crawford and A. Ahluwalia} } @article {1278, title = {Supporto per camere di coltura cellulare}, year = {2011}, month = {11/2011}, keywords = {Bioengineering}, issn = {MI2011A002073}, author = {A. Ahluwalia and Sbrana, T. and D. Mazzei} } @article {1276, title = {Contenitore per alimenti caldi e simili}, year = {2010}, keywords = {Bioengineering}, issn = {PI2009A000145}, author = {M. Bonini and R. Casati and M. Falorni and G Fantoni and M. Massei and D. Mazzei and M. Mazzuoli and G. Renucci} } @conference {1271, title = {The FACE of autism}, booktitle = {Proc. IEEE RO-MAN}, year = {2010}, pages = {791{\textendash}796}, keywords = {Bioengineering}, doi = {10.1109/ROMAN.2010.5598683}, author = {D. Mazzei and Billeci, L. and Armato, A. and Lazzeri, N. and Cisternino, A. and G. Pioggia and Igliozzi, R. and Muratori, F. and A. Ahluwalia and D. De Rossi} } @article {1332, title = {Finite element modelling and design of a concentration gradient generating bioreactor: Application to biological pattern formation and toxicology}, journal = {Toxicology in vitro}, volume = {24}, year = {2010}, pages = {1828{\textendash}1837}, abstract = {

This paper describes the use of a microfluidic gradient maker for the toxicological analysis of some conventional biomolecules such as hydrogen peroxide and a local anaesthetic, lidocaine on different cell cultures, human endothelial cells and myoblasts, respectively. The microfluidic device was designed and simulated using COMSOL Multiphysics(R) and the concentration gradient in the microfluidic network was analysed through a fluid-dynamic and mass-transport study. Subsequently the device was fabricated with soft lithography, casting PDMS in a master to obtain channels about 250mum deep. Hydrogen peroxide was tested on human endothelial cells, while lidocaine was tested on C2C12 myoblasts and an analysis was performed using propidium iodide staining followed by an imaging processing routine to obtain quantitative dose-response profiles in the gradient maker. The results show that the Gradient Maker (GM) bioreactor is a more sensitive method for detection of cell toxicity, and compared with testing of drug toxicity using microwells with individual cell cultures, allows one shot testing with a single cell culture exposed to a large number of concentrations. Moreover, the Gradient Maker was also modelled in order to realise biological pattern formation using two morphogenes acting as activator and inhibitor with varying diffusion rates.

}, keywords = {Bioengineering}, issn = {1879-3177}, doi = {10.1016/j.tiv.2010.05.010}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20580814}, author = {G. Vozzi and D. Mazzei and Tirella, A and Vozzi, F. and A. Ahluwalia} } @article {1284, title = {In vitro liver model using microfabricated scaffolds in a modular bioreactor.}, journal = {Biotechnol J}, volume = {5}, year = {2010}, month = {Feb}, pages = {232{\textendash}241}, abstract = {

Hepatocyte function on 3-D microfabricated polymer scaffolds realised with the pressure-activated microsyringe was tested under static and dynamic conditions. The dynamic cell culture was obtained using the multicompartment modular bioreactor system. Hepatocyte cell density, glucose consumption, and albumin secretion rate were measured daily over a week. Cells seeded on scaffolds showed an increase in cell density compared with monolayer controls. Moreover, in dynamic culture, cell metabolic function increased three times in comparison with static monolayer cultures. These results suggest that cell density and cell-cell interactions are mediated by the architecture of the substrate, while the endogenous biochemical functions are regulated by a sustainable supply of nutrients and interstitial-like flow. Thus, a combination of 3-D scaffolds and dynamic flow conditions are both important for the development of a hepatic tissue model for applications in drug testing and regenerative medicine.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.1002/biot.200900074}, author = {Vinci, B. and Cavallone, D. and G. Vozzi and D. Mazzei and C. Domenici and Brunetto, M. and A. Ahluwalia} } @article {1283, title = {A low shear stress modular bioreactor for connected cell culture under high flow rates.}, journal = {Biotechnol Bioeng}, volume = {106}, year = {2010}, month = {May}, pages = {127{\textendash}137}, abstract = {

A generic "system on a plate" modular multicompartmental bioreactor array which enables microwell protocols to be transferred directly to the bioreactor modules, without redesign of cell culture experiments or protocols is described. The modular bioreactors are simple to assemble and use and can be easily compared with standard controls since cell numbers and medium volumes are quite similar. Starting from fluid dynamic and mass transport considerations, a modular bioreactor chamber was first modeled and then fabricated using "milli-molding," a technique adapted from soft lithography. After confirming that the shear stress was extremely low in the system in the range of useful flow rates, the bioreactor chambers were tested using hepatocytes. The results show that the bioreactor chambers can increase or maintain cell viability and function when the flow rates are below 500 microL/min, corresponding to wall shear stresses of 10(-5) Pa or less at the cell culture surface.

}, keywords = {Bioengineering, Bioreactors}, doi = {http://dx.doi.org/10.1002/bit.22671}, author = {D. Mazzei and M. A. Guzzardi and S. Giusti and A. Ahluwalia} } @article {1282, title = {Modification of Pointing Performance in Altered Gravitational Environments}, journal = {Microgravity Science and Technology}, volume = {22}, year = {2010}, note = {

10.1007/s12217-009-9163-3

}, pages = {123-128}, abstract = {

The Fitts{\textquoteright} law describes a correlation between the time needed to complete basic tasks such as pointing movements and the level of knowledge of the specific target to be reached. While it has been largely proved in normal gravity, very few experiments have been carried out in altered gravitational conditions. In our experiment, four subjects were positioned in front of a panel where round targets were placed along a circumference. They carried out pointing movements towards the targets when these were switched on. The task time was acquired and processed off-line. In all the cases, the performance of each subject have been significantly modified in the altered gravitational environment and, in particular, hypergravity seems to affect motor performance more considerably than microgravity. Even if experiments involving several subjects and more complex tasks have to be carried out in order to confirm our findings, these results show that ergonomics could be strongly affected by the modification of gravity, especially during the first phase of exposure to gravity alteration.

}, keywords = {Bioengineering}, issn = {0938-0108}, doi = {http://dx.doi.org/10.1007/s12217-009-9163-3}, author = {Ciofani, G. and Migliore, A. and D. Mazzei and Carrozza, M. and P. Dario} } @article {1281, title = {A High-Throughput Bioreactor System for Simulating Physiological Environments}, journal = {IEEE T Ind Electron}, volume = {55}, year = {2008}, pages = {3273{\textendash}3280}, keywords = {Bioengineering}, doi = {10.1109/TIE.2008.928122}, author = {D. Mazzei and Vozzi, F. and Cisternino, A. and G. Vozzi and A. Ahluwalia} } @article {1275, title = {IMPROVED BIOREACTOR CHAMBER}, year = {2008}, keywords = {Bioengineering}, issn = {P121684GB}, author = {A. Ahluwalia and D. Mazzei and Vozzi, F.} } @conference {1794, title = {Microfluidic Gradient Maker for Pattern Generation}, booktitle = {TERMIS-EU}, year = {2008}, pages = {879}, address = {Porto, Portugal}, abstract = {

poster

}, keywords = {Bioengineering}, author = {Tirella, A and D. Mazzei and G. Vozzi and A. Ahluwalia} } @article {1274, title = {MULTI-CAVITY BIOREACTOR CHAMBER}, year = {2008}, keywords = {Bioengineering}, issn = {P122454GB}, author = {A. Ahluwalia and D. Mazzei and Vinci, B.} } @conference {1270, title = {Design and realisation of drop-free trocar for ophthalmic applications}, booktitle = {Proc. IEEE Int. Symp. Industrial Electronics ISIE 2007}, year = {2007}, pages = {2810{\textendash}2814}, keywords = {Bioengineering}, doi = {10.1109/ISIE.2007.4375056}, author = {Guerrini, P. and G. Vozzi and A. Ahluwalia and D. Mazzei and Palla, M. and Rizzo, S.} } @conference {1269, title = {Development of a high-throughput bioreactor system for biomedical applications}, booktitle = {Proc. IEEE Int. Symp. Industrial Electronics ISIE 2007}, year = {2007}, pages = {2788{\textendash}2792}, keywords = {Bioengineering}, doi = {10.1109/ISIE.2007.4375051}, author = {D. Mazzei and G. Vozzi and A. Ahluwalia and Cisternino, A.} } @article {1273, title = {Sensore di flusso tattile e di parametri ambientali}, year = {2006}, keywords = {Bioengineering}, issn = {PI2006A000119}, author = {G. Vozzi and Cisternino, A. and Colombo, D. and D. Mazzei and Migliore, A.} } @conference {1268, title = {Functional and Pharmacological testing of endothelial cells cultured in dynamic conditions}, booktitle = {Proceedings of: XIV Edizione del Congresso della Fisiologia Clinica-CNR}, year = {2005}, pages = {82-96}, keywords = {Bioengineering}, author = {Vozzi, F. and Gentile, C. and D. Mazzei and G. Vozzi and C. Domenici and A. Ahluwalia} } @article {1280, title = {Osmolality control by inhalation or micro-infusions?}, journal = {WIT Transactions on Biomedicine and Health}, volume = {9}, year = {2005}, pages = {559-570}, abstract = {

A model of osmolarity is proposed in this paper. This model represents a typical example of embedded physiological feedback control in physiology. Extensive simulation tests with a compartmental approach (using the specific software SAAM II) have been performed, showing that the model agrees with the findings published in the literature of endocrine physiology and with medical practice. As a relevant example of application of the models, the diabetes insipidus pathology was considered. In the case of central insipidus diabetes, it is possible to predict effects of a therapy, giving out synthetic ADH (where ADH is the antidiuretic hormone, the vasopressine) for restoring homeostatic conditions. Two kinds of therapy were considered: supply by inhalation or by microinfusion. In the first case, we evaluated the effect of inhalation using a two compartmental model to describe the effect of commercial drug (minirin, that means desmopressine acetate), and compared results with data existing in the literature. In the second case, the aim was to have a helping tool in the study and development of micro-infusors with sensors and controllers embedded so as to be able to release a controlled drug quantity, accorded to the patient and optimized for avoiding hyper- or ipo-concentrations of plasma ADH hormone. In this case, we used a mono-compartmental model, considering that the drug is infused directly in the plasma; results are again compared with data existing in the literature and with experimental data.

}, keywords = {Bioengineering}, author = {Ciofani, G. and A. Landi and D. Mazzei and A. Mazzoldi} } @conference {1266, title = {Physiological Cybernetics: Model of Osmolality and Volemia}, booktitle = {Proc. and 2005 European Control Conf. Decision and Control CDC-ECC {\textquoteright}05. 44th IEEE Conf}, year = {2005}, pages = {5552{\textendash}5557}, keywords = {Bioengineering}, doi = {10.1109/CDC.2005.1583046}, author = {Ciofani, G. and A. Landi and D. Mazzei and A. Mazzoldi} } @conference {1267, title = {Realisation of a concentration gradients cell chamber to study their effect of biomolecules on the cell activity}, booktitle = {Proceedings of: 4Th Annual Meeting of the European Tissue Engineering Society (ETES)}, year = {2005}, keywords = {Bioengineering}, author = {D. Mazzei and Vozzi, F. and G. Vozzi and A. Ahluwalia} }